Twenty-three defendants faced the tribunal, which heard extensive evidence about experiments and killing programmes. Prisoners had been exposed to freezing, pressure, infection, drugs, wounds, sterilisation, and other violence without consent. The ethical text belongs inside that history of persecution and testimony, not only inside a progressive chronology of regulation.
Prosecution advisers Leo Alexander and Andrew Ivy helped formulate standards during the trial; the judges revised proposed points into ten principles. The code was not initially a freestanding treaty, and its direct legal force remained uncertain. Nevertheless, it became a landmark reference for later ethics declarations and debates.
Unethical research continued after 1947, including within countries that celebrated Nuremberg. That persistence exposes the weakness of treating codes as self-enforcing. Institutional review, transparent methods, accountability, participant power, and attention to structural coercion are required to make principles operational.