Horton was born in Gloucester near Freetown to parents of Igbo ancestry who had been liberated from slave ships and resettled in Sierra Leone. He attended Church Missionary Society schools and Fourah Bay Institution, part of a Creole intellectual world shaped by Atlantic slavery, Christianity, commerce, and British colonial rule.
A War Office scholarship took him to Britain in 1855. He studied at King's College London, won academic recognition, and completed an MD at Edinburgh in 1859. As a student he adopted “Africanus,” marking an identification that his later political writing made explicit.
Commissioned as a staff assistant surgeon, Horton served in the Gold Coast and elsewhere in West Africa for roughly twenty years. Military postings gave him wide experience but tied his practice to expeditions, colonial administration, and the violent expansion of British authority.
- 1835: Horton is born near Freetown, Sierra Leone.
- 1855: a War Office scholarship sends him to Britain for medical training.
- 1859: he completes his Edinburgh MD and enters British military medical service.
- 1860s: medical and political publications connect public health to racial and institutional reform.
- 1880-1883: after military retirement, he pursues commercial projects before his early death.