Last centuries BCE to about 500 CE: Linguistic, intertextual, and structural evidence points to successive composition and redaction. Current scholarship allows an early core in the last centuries BCE and places the received form by roughly the fourth or fifth century CE; it rejects the often-repeated date of exactly 600 BCE for the whole work (Wujastyk 2026).
Late eighth or early ninth century: The tenth-century Baghdadi bibliographer Ibn al-Nadīm reported that the Indian physician-translator Mankah rendered a work called Kitāb Susrud for the Barmakid patron Yaḥyā ibn Khālid. The translation itself has not survived, so its language, extent, wording, and impact cannot be reconstructed merely from the catalogue notice (Vagelpohl and Sánchez 2022).
878 CE: A palm-leaf manuscript now catalogued as Kathmandu Kaiser Library 699 was copied by several scribes and dated in its colophon. It is the oldest reliably dated substantial witness to the compendium. Announced to scholars in 2007, it preserves a recension significantly different from later printed editions (Suśruta Project; Wujastyk et al. 2023).
Around the twelfth century: Ḍalhaṇa's Nibandhasaṅgraha interpreted vocabulary, identified variant readings, cited earlier authorities, and helped shape the version familiar from modern editions. His commentary is not neutral packaging: it is evidence for medieval scholarship and for a stage of the Sanskrit text later than the Nepalese recension (Suśruta Project).
1907–1916 and 1938: Kaviraj Kunjalal Bhishagratna published the first complete English translation in three volumes in Calcutta. Jādavji Trikamji Ācārya and Nārāyaṇ Rām Ācārya's 1938 Bombay Sanskrit edition printed the root text with Ḍalhaṇa and, for part of the Nidānasthāna, Gayadāsa. Both greatly widened access while fixing particular readings that later readers often mistook for a single ancient original (Bhishagratna 1907–1916; SARIT).
2020 to the present: The Suśruta Project has transcribed KL 699 and related Nepalese manuscripts, linked readings to manuscript images, and released an evolving digital critical edition. Its work demonstrates that medical history changes when historians compare physical witnesses rather than relying only on familiar print (Critical edition).