Galen wrote across many genres rather than producing one definitive textbook. Anatomical treatises, therapeutic works, commentaries, case discussions, pharmacology, and polemics addressed different audiences and problems. Calling the result a synthesis describes the connections he argued for, not a single volume completed on one date.
His forceful criticism of rivals shaped survival and later reputation. Readers often encountered earlier physicians through Galen's summaries and judgements, which means his writing preserved arguments while directing how they should be understood. Authority grew from rhetoric as well as experiment and practice.
Transmission then selected among this large output. Some Greek works vanished but survived in Arabic; others circulated in shortened or rearranged form. The Galenic system inherited by a medieval Arabic physician or an early modern European anatomist was therefore produced by translators, commentators, teachers, and available manuscripts.